SÉMINAIRES DE L’UNF
|Présentateur:||Joana Pereira, Ph.D.|
|Titre:||Alterations of the brain connectome as an early indicator of Alzheimer’s disease|
|Endroit:||CRIUGM – Local E1910 (http://www.criugm.qc.ca/en/contact.html)|
|Date:||Mercredi 21 août 2019, 11h00-12h00|
*La conférence sera présentée en anglais
Dr. Pereira is an associate professor at the Division of Clinical Geriatrics. She has a PhD in Biomedicine by the University of Barcelona. Dr Pereira is working with structural MRI, functional MRI and diffusion tensor imaging in patients with Alzheimer’s disease and Parkinson’s disease. Her current projects are focused on the assessment of brain connectivity and network topology in preclinical and clinical stages of these disorders.
Alzheimer’s disease (AD) is a neurological disorder with a long preclinical phase that typically extends over two decades. As AD progresses, amyloid plaques and neurofibrillary tangles spread in the brain according to a characteristic spatial pattern. Since this spread along connected brain regions is associated with the development of cognitive decline and dementia, alterations of brain connectivity can identify individuals with early AD and predict their progression. The entire network of connections between brain regions is known as the brain connectome. In this talk, I will present evidence that changes in the brain connectome can be used to identify individuals at high risk of developing AD and I will also compare them with connectome changes in another prevalent neurodegenerative disorder – Parkinson’s disease.