Séminaire Joana Pereira

Tweet SÉMINAIRES DE L’UNF Présentateur: Joana Pereira,  Ph.D. Titre: Alterations of the brain connectome as an early indicator of Alzheimer’s disease Endroit: CRIUGM – Local E1910 (http://www.criugm.qc.ca/en/contact.html) Date: Mercredi 21 août 2019, 11h00-12h00 *La conférence sera présentée en anglais Dr. Pereira is an associate professor at the Division of Clinical Geriatrics. She has a PhD in Biomedicine by the University of Barcelona. Dr Pereira is working with structural MRI, functional MRI and diffusion tensor imaging in patients with Alzheimer’s disease and Parkinson’s disease. Her current projects are focused on the assessment of brain connectivity and network topology in preclinical and clinical stages of these disorders.   Abstract: Alzheimer’s disease (AD) is a neurological disorder with a long preclinical phase that typically extends over two decades. As AD progresses, amyloid plaques and neurofibrillary tangles spread in the brain according to a characteristic spatial pattern. Since this spread along connected brain regions is associated with the development of cognitive decline and dementia, alterations of brain connectivity can identify individuals with early AD and predict their progression. The entire network of connections between brain regions is known as the brain connectome. In this talk, I will present evidence that changes in the brain connectome can be used to identify individuals at high risk of developing AD and I will also compare them with connectome changes in another prevalent neurodegenerative disorder – Parkinson’s...

Séminaire Clare Kelly

Tweet SÉMINAIRES DE L’UNF Présentateur: Clare Kelly,  Ph.D. Titre: Progress and promise of fMRI functional connectomics for neuropsychiatric disorders Endroit: CRIUGM – Amphithéâtre Le Groupe Maurice (http://www.criugm.qc.ca/en/contact.html) Date: Mercredi 14 août 2019, 13h00-14h00 *La conférence sera présentée en anglais Dr. Clare Kelly graduated from Trinity with her BA in 2002 and PhD in 2006 (Psychology). She spent the next nine years at New York University School of Medicine, where she made key contributions to the field of functional connectomics, a network-based technique that examines patterns of synchronised brain activity to provide a comprehensive, non-invasive map of brain circuitry. Her work includes seminal demonstrations of the clinical, developmental, and translational utility of functional connectomics for our understanding of healthy and disordered brain function. In January 2015, Clare returned to Trinity College to become an Ussher Assistant Professor of Functional Neuroimaging, working at Trinity College Institute of Neuroscience (TCIN), the School of Psychology, and Department of Psychiatry at the School of Medicine. At TCD, Clare uses translational brain imaging techniques to examine the links between how children and adolescents behave, think, and react to their worlds and how their brains are organised. Her studies aim to better understand psychiatric conditions such as depression and Autism and to improve treatments by tracing the origins of these conditions in the developing brain. Clare’s Google Scholar Author Profile is available here: http://scholar.google.com/citations?user=1_bjrikAAAAJ&hl=en   Abstract: Task-independent or “resting state” functional magnetic resonance imaging (fMRI) approaches (“functional connectomics”) have revolutionized our understanding of brain functional organisation and have driven significant advances toward the goal of identifying valid and reliable biomarkers of psychiatric illness. Yet, despite the rapid growth of the field, together with...

Séminaire Christoph T. Weidemann

Tweet SÉMINAIRES DE L’UNF Présentateur: Christoph T. Weidemann,  Ph.D. Titre: The dynamics of memory – Decoding brain activity with machine learning Endroit: CRIUGM – Local E1910 (http://www.criugm.qc.ca/en/contact.html) Date: Mardi 23 juillet 2019, 13h30-14h30 *La conférence sera présentée en anglais Dr. Weidemann is an associate professor in the Department of Psychology at Swansea University in Wales (UK) and currently also a visiting scholar at the University of Pennsylvania. In 2006 he obtained a PhD in Psychology and Cognitive Science (with a minor in Neuroscience) from Indiana University where he worked with Richard Shiffrin. He then joined Mike Kahana’s lab at the University of Pennsylvania as a post-doc and took up a faculty position at Swansea University in 2010. His website is at http://cogsci.info   Abstract: Even though encoding and retrieval processes are both critical determinants of performance in memory tests, only their joint effects are observable in overt behavior. This has led to contentious debates about the nature of the signal elicited by recognition memory probes and about the relative contributions of encoding and retrieval processes in interactions between semantic and episodic memory systems. Using machine learning techniques to quantify relevant signals in brain activity as they unfold during engagement in memory tasks I will address these controversies. Specifically, I will present evidence for a single-route account of recognition memory that is compatible with contributions from familiarity and recollection signals, but relies on a unitary evidence signal that integrates all available evidence. I will also particularly implicate retrieval (rather than encoding) processes in the categorical organization of episodic...

Séminaire Muhammad Saleh

Tweet SÉMINAIRES DE L’UNF Présentateur: Muhammad Saleh,  Ph.D. Titre: Universal MRS sequences for single- and multi-metabolite editing. Endroit: CRIUGM – Local M6804 (http://www.criugm.qc.ca/en/contact.html) Date: Vendredi 17 mai 2019, 13h30-14h30 *La conférence sera présentée en anglais Muhammad Saleh is a postdoctoral fellow in the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine. Originally from the beautiful island of Zanzibar, Tanzania. He received his Ph.D. from the University of Cape Town, South Africa, involving prospective motion and magnetic field correction during GABA editing followed by in vivo applications. As a fellow at Hopkins, he develops novel methods for measuring brain metabolites, including inhibitory neurotransmitter GABA and marker of oxidative stress glutathione (GSH), under the mentorship of Professor Edden. Recently, he standardized these methods across all four major vendors, Philips, Siemens, GE, and Canon, and disseminated to more than 15 site nationally and internationally to study the pathophysiology of a broad range of neurological diseases. He continues to provide support and collaborates with the researchers from different sites, ranging from acquisition to post-processing and quantification of data using Gannet analysis package.   Abstract: Magnetic Resonance Spectroscopy (MRS) is a non-invasive methodology that allows the quantification of endogenous metabolites in the human body, including the inhibitory neurotransmitter GABA and redox compound glutathione (GSH) in the brain. However, due to their low concentration, measurement of GABA and GSH using conventional single-voxel MRS is difficult, and at 3T, spectral editing (MEGA-PRESS) is typically used. In this seminar, he will describe how GABA and GSH can be measured in the brain using spectral editing, including some of the limitations of...

Séminaire Petra Ritter

Tweet SÉMINAIRES DE L’UNF Présentateur: Prof. Dr. Petra Ritter Titre: The Virtual Brain – Improving life through simulation Endroit: CRIUGM – Local E1910 (http://www.criugm.qc.ca/en/contact.html) Date: Mercredi 8 mai 2019, 16h-17h *La conférence sera présentée en anglais Prof Ritter is a computational neuroscientist and medical doctor at Charité in Berlin. One of her central research topics is the development of brain simulations for individual people with neurological conditions, combining EEG and neuroimaging data. Prof Ritter studied medicine at Humboldt University Berlin. She did residencies at UCLA, UCSD, Mount Sinai School of Medicine in New York, and Harvard Medical School, as well as Charité. She completed her doctoral thesis in 2004 at Charité under Arno Villringer. She is a cofounder of The Virtual Brain open-source brain simulation platform. Since October 2017 she has held a lifetime BIH Johanna-Quandt Full Professorship of Brain Simulation at the Dept. of Neurology at the Charité and Berlin Institute of Health.   Links: Petra Ritter @ Berlin Institute for Health (BIH) https://www.bihealth.org/en/research/research-groups/bih-johanna-quandt-professorships/petra-ritter/   Brain Simulation https://brainsimulation.charite.de/en/   Petra Ritter’s publications...